Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in HIV– tuberculosis patients

Kabeer, Basirudeen S A and Sikhamani, R and Raja, A (2010) Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in HIV– tuberculosis patients. AIDS, 24 (2). pp. 323-325. ISSN Print: 0269-9370 Electronic: 1473-5571

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Abstract

Interferon gamma (IFNg)-based in-vitro assays have suboptimal sensitivity, especially in immunocompromised individuals, which emphasizes the need for alternative markers for tuberculosis (TB) diagnosis. We compared TB antigens-specific IFNg and IFNg-inducible protein-10 levels in culture of whole blood samples from HIV–TB patients. We report that IFNg-inducible protein- 10 detects a greater number of HIV–TB cases than IFNg and suggest that IFNg-inducible protein-10 may be a better alternative marker for latent TB infection diagnosis among immunocompromised individuals.

Affiliation:	National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/1019

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