Cellular immune response to Mycobacterium tuberculosis-speciWc antigen culture Wltrate protein-10 in south India

Kumar, Madhan and Sundaramurthi, J C and Mehra, Narinder K and Kaur, Gurvinder and Raja, Alamelu (2010) Cellular immune response to Mycobacterium tuberculosis-speciWc antigen culture Wltrate protein-10 in south India. Medical Microbiology and Immunology, 199 (1). pp. 11-25. ISSN Print: 0300-8584 | Electronic: 1432-1831

[thumbnail of Embargo12 Months] Archive (Embargo12 Months)
201009.pdf - Published Version

Download (654kB)

Abstract

The Mycobacterium tuberculosis (M. tuberculosis)- speciWc culture Wltrate protein-10 (CFP-10) is highly recognized by M. tuberculosis infected subjects. In the present study, the proliferative response and IFN-� secretion was found for C-terminal peptides of the protein (Cfp651–70, Cfp761–80, Cfp871–90, and Cfp981–100). The alleles HLA DRB1 *04 and HLA DRB1 *10 recognized the C-terminal peptides Cfp7, Cfp8, and Cfp9 in HHC. Cfp6 was predominantly recognized by the alleles HLA DRB1 *03 and HLA DRB1 *15 by PTB. The minimal nonameric epitopes from the C-terminal region were CFP-1056–64 and CFP-1076–84. These two peptides deserve attention for inclusion in a vaccine against tuberculosis in this region.

Affiliation: National Institute for Research in Tuberculosis
Item Type: Article
Uncontrolled Keywords: CFP-10 · HLA analysis · Epitope mapping · Overlapping peptides · Proliferation · Interferon gamma · In silico CFP-10 · IL-4 · ELISA · Tuberculosis
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 17 Mar 2022 10:11
Last Modified: 17 Mar 2022 10:13
URI: http://eprints.nirt.res.in/id/eprint/1025

Actions (login required)

View Item View Item