Genetic susceptibility in tuberculosis

Yim, Jae-Joon and Selvaraj, Paramasivam (2010) Genetic susceptibility in tuberculosis. Respirology, 15 (2). pp. 241-256. ISSN Print: 1323-7799 | Electronic: 1440-1843

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Abstract

The importance of host genetic factors in determining susceptibility to tuberculosis (TB) has been studied extensively using various methods, such as casecontrol, candidate gene and genome-wide linkage studies. Several important candidate genes like human leucocyte antigen/alleles and non-human leucocyte antigen genes, such as cytokines and their receptors, chemokines and their receptors, pattern recognition receptors (including toll-like receptors, mannose binding lectin and the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin), solute carrier family 11A member 1 (formerly knownas natural resistance-associated macrophage protein 1) and purinergic P2X7 receptor gene polymorphisms, have been associated with differential susceptibility to TB in various ethnic populations. This heterogeneity has been explained by host–pathogen and gene– environment interactions and evolutionary selection pressures. Although the achievements of genetics studies might not yet have advanced the prevention and treatment of TB, researchers have begun to widen their scope of investigation to encompass these practical considerations.

Affiliation:	National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Genetic, tuberculosis
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	17 Mar 2022 11:06
Last Modified:	17 Mar 2022 11:06
URI:	http://eprints.nirt.res.in/id/eprint/1028

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