Swaminathan, Soumya and Padmapriyadarshini, C and Narendran, G (2010) HIV-Associated Tuberculosis: Clinical Update. Clinical Infectious Diseases, 50. pp. 1377-1386. ISSN Print: 1058-4838 | Electronic: 1537-6591
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Abstract
The human immunodeficiency virus (HIV) epidemic has led to an increase in the incidence of tuberculosis globally, particularlyin sub-Saharan Africa. Coinfection with HIV leads to difficulties in both the diagnosis and treatment of tuberculosis. Becauseof the poor performance of sputum smear microscopy in HIV-infected patients, more sensitive tests—such as liquid culturesystems, nucleic acid amplification assays, and detection of mycobacterial products in various body fluids—are being inves-tigated. The treatment of coinfected patients requires antituberculosis and antiretroviral drugs to be administered concom-itantly; challenges include pill burden and patient compliance, drug interactions, overlapping toxic effects, and immunereconstitution syndrome. Both multidrug-resistant and extensively drug-resistant tuberculosis can spread rapidly among animmunocompromised population, with resulting high mortality rates. Current guidelines recommend starting antiretroviraltreatment within a few weeks of antituberculosis therapy for patients with CD4 cell counts!350 cells/mL; however, importantquestions about the drug regimens and timing of antiretroviral therapy remain. Ongoing trials may answer many of theseunresolved questions.
Affiliation: | ICMR-National Institute for Research in Tuberculosis |
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Item Type: | Article |
Uncontrolled Keywords: | HIV, Tuberculosis |
Subjects: | Tuberculosis > Clinical Research |
Divisions: | Clinical Research |
Depositing User: | Dr. Rathinasabapati R |
Date Deposited: | 24 Mar 2022 07:28 |
Last Modified: | 24 Mar 2022 07:28 |
URI: | http://eprints.nirt.res.in/id/eprint/1043 |
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