Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro- Inflammatory Cytokine Response (CURES 83)

Aravindhan, V and Viswanathan, Mohan and Surendar, Jayagopi and Muralidhara Rao, Maradana and Pavan Kumar, N and Deepa, Mohan and Rajagopalan, Ramanujam and Kumaraswami, V and Nutman, Thomas B and Babu, Subash (2010) Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro- Inflammatory Cytokine Response (CURES 83). PLOS Neglected Tropical Diseases, 4 (6). e707. ISSN Electronic: 1935-2735 | Print: 1935-2727

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Abstract

Epidemiological studies have shown an inverse correlation between the incidence of lymphatic filariasis (LF) and the incidence of allergies and autoimmunity. However, the interrelationship between LF and type-2 diabetes is not known and hence, a cross sectional study to assess the baseline prevalence and the correlates of sero-positivity of LF among diabetic subjects was carried out (n = 1416) as part of the CURES study. There was a significant decrease in the prevalence of LF among diabetic subjects (both newly diagnosed [5.7%] and those under treatment [4.3%]) compared to pre-diabetic subjects [9.1%] (p = 0.0095) and non-diabetic subjects [10.4%] (p = 0.0463). A significant decrease in filarial antigen load (p = 0.04) was also seen among diabetic subjects. Serum cytokine levels of the pro-inflammatory cytokines—IL-6 and GMCSF— were significantly lower in diabetic subjects who were LF positive, compared to those who were LF negative. There were, however, no significant differences in the levels of anti-inflammatory cytokines—IL-10, IL-13 and TGF-b—between the two groups. Although a direct causal link has yet to be shown, there appears to be a striking inverse relationship between the prevalence of LF and diabetes, which is reflected by a diminished pro-inflammatory cytokine response in Asian Indians with diabetes and concomitant LF.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Lymphatic, Filariasis, Diabetic, Pro-inflammatory, Cytokine, CURES
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	25 May 2022 06:49
Last Modified:	25 May 2022 10:43
URI:	http://eprints.nirt.res.in/id/eprint/1049

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