Major histocompatibility complex class III (C2, C4, factor B) and C3 gene variants in patients with pulmonary tuberculosis

Senbagavalli, P and Kumar, N and Kaur, Gurvinder and Mehra, N K and Geetha, S T and Ramanathan, V D (2011) Major histocompatibility complex class III (C2, C4, factor B) and C3 gene variants in patients with pulmonary tuberculosis. Human Immunology, 72 (2). pp. 173-178. ISSN 0198-8859

Archive 201104.pdf - Published Version Restricted to Registered users only Download (484kB) | Request a copy

Abstract

The complement system is an integral part of the host immune system and plays an immunoregulatory role at the interface of innate and acquired immune responses. Limited data are available on the influence of variations in complement genes in infectious diseases such as pulmonary tuberculosis (PTB). The aim of this study was to investigate the role of genetic variations in complement system components C2, C4, BF, and C3 in PTB (n�125) compared with healthy controls (n�125) in the Indian population. The study showed, for the first time, an increased occurrence of null alleles at the C4A, i.e., C4AQ0; an increased frequency of BF*FA and C3*F in patients with PTB compared with healthy individuals, and contributed a risk with odds ratios of 18.16 (95% confidence interval [CI] � 3.0–108.6, p � 0.0004), 2.9 (95% CI � 1.9–4.37, pc � 3.15E-06), and 2.26 (95% CI � 1.5–3.3, pc � 6.7E-05), respectively. A combinatorial analysis of complement gene variants as risk determinants and their phenotypic effects in various populations may provide unique insights into the genetic basis of susceptibility to PTB.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Complement gene variants, Pulmonary tuberculosis, Innate immune system, Indian population
Subjects:	Tuberculosis > Laboratory Research > Pathological
Divisions:	Basic Science Research > Clinical Pathology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	16 Jun 2022 05:53
Last Modified:	16 Jun 2022 05:53
URI:	http://eprints.nirt.res.in/id/eprint/1080

Actions (login required)

View Item