Vitamin D, Vitamin D Receptor, and Cathelicidin in the Treatment of Tuberculosis

Selvaraj, P (2011) Vitamin D, Vitamin D Receptor, and Cathelicidin in the Treatment of Tuberculosis. In: Vitamins and Hormones. [error in script], pp. 307-325. ISBN 0083-6729

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Abstract

vitamin D receptor (VDR) that are present in various cells of the immune system. Vitamin D deficiencies have been associated with development of tuberculosis (TB) disease, caused by Mycobacterium tuberculosis. Vitamin D3 is shown to enhance macrophage phagocytosis of M. tuberculosis and increases the production of antimicrobial peptide cathelicidin and killing of M. tuberculosis. During the preantibiotic era, exposure to sunlight and supplementation of vitamin D were the methods of choice for treatment of TB. Vitamin D supplementation showed sputum clearance and radiological improvement and reduction in mortality among human immunodeficiency virus (HIV)-infected patients with TB. VDR gene polymorphisms regulate the immunomodulatory effect of vitamin D3 and are associated with faster sputum conversion during anti-TB treatment. The emerging evidences regarding immunomodulatory properties of vitamin D3 have rekindled interest in vitamin D as an adjunct to anti-TB therapy. The current review explains the important potential application of vitamin D in enhancing the innate immunity to TB and the role of VDR gene variants on anti-TB treatment.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Book Section
Uncontrolled Keywords:	Vitamin-D, Vitamin-D receptor, Cathelicidin, Tuberculosis
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	16 Jun 2022 10:06
Last Modified:	16 Jun 2022 10:06
URI:	http://eprints.nirt.res.in/id/eprint/1087

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