Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents

Karthik Kumar, K and Prabu Seenivasan, S and Kumar, Vanaja and Das, T M (2011) Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents. Carbohydrate Research, 346 (14). pp. 2084-2090. ISSN 0008-6215

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Abstract

series of quinoline coupled 1,2,3-triazoles compounds have been synthesized by ‘click chemistry’ from azidomethyl quinoline with different alkynes. The efficiency and fidelity of the Cu(I)-catalyzed azide– alkyne reaction are substantiated by good yields and exclusive formation of the expected 1,4-disubstituted triazole product. All the synthesized compounds were screened for anti-tubercular activity against Mycobacterium tuberculosis H37Rv by luciferase reporter phage (LRP) assay. Quinoline coupled triazole sugar hybrid, 20 is the most potent compound in the series with 76.41% and 78.37% reduction calculated based on percentage reduction in Relative Light Units at 5 and 25 lg/mL, respectively.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Quinoline derivatives Click chemistry Cu(I) catalysed Anti-tubercular activity Saccharide, triazole, derivatives, Mycobacterium tuberculosis, H37Rv
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	21 Jun 2022 09:18
Last Modified:	21 Jun 2022 09:18
URI:	http://eprints.nirt.res.in/id/eprint/1115

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