Extensively drug-resistant tuberculosis: experience at the Tuberculosis Research Centre, Chennai, India

Thomas, A and Joseph, P and Nair, D and Rao, D V B and Rekha, V V B and Selvakumar, N and Jaggarajamma, K and Balambal, R (2011) Extensively drug-resistant tuberculosis: experience at the Tuberculosis Research Centre, Chennai, India. International Journal of Tuberculosis and Lung Disease, 15 (10). pp. 1323-1325. ISSN Print: 1027-3719 | Electronic: 1815-7920

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Abstract

Ten extensively drug-resistant tuberculosis (XDR-TB) patients were identifi ed among 104 human immunodefi - ciency virus negative multidrug-resistant tuberculosis (MDR-TB) patients treated at the Tuberculosis Research Centre, Chennai, India, in two different cohorts between 1999–2003 and 2006–2007. They were managed with individualised treatment regimens. At the time of diagnosis of MDR-TB, one patient had XDR-TB and three had initial ofl oxacin resistance. One patient who had had a lobectomy in addition to chemotherapy became bacteriologically negative, three died, three defaulted and the remaining three, who are bacteriologically positive, are still continuing treatment. Although based on a small number of patients, our results have not been encouraging.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	tuberculosis; drug resistance; XDR-TB; second-line drugs; management
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	21 Jun 2022 11:27
Last Modified:	21 Jun 2022 11:27
URI:	http://eprints.nirt.res.in/id/eprint/1117

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