Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel

Graham, S M and Ahmed, M and Amanullah, F and Browning, R and Cardenas, V and Casenghi, M and Cuevas, L E and Gale, M and Gie, R P and Gizemska, M and Handelsman, Ed and Hatherill, M and Hesseling, A C and Jean-Phillippe, P and Kampmann, B and Kabra, S K and Lienhardt, C and Lighter-Fisher, J and Madhi, S and Makhene, M and Marais, B and McNeeley, D F and Menzies, H and Mitchel, C and Modi, S and Mofenson, L and Musoke, P and Nachman, S and Powell, C and Rigaud, M and Rouzier, V and Starke, J R and Swaminathan, Soumya and Wingfield, C (2012) Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel. Journal of Infectious Diseases, 205 (Supl.2). S199-S208. ISSN Print: 0022-1899 | Electronic: 1537-6613

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Abstract

There is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case definitions for the evaluation of diagnostics in prospective clinical research studies that include children in whom tuberculosis is suspected but not confirmed by culture of Mycobacterium tuberculosis. A panel representing a wide range of expertise and child tuberculosis research experience aimed to develop standardized clinical research case definitions for intrathoracic tuberculosis in children to enable harmonized evaluation of new tuberculosis diagnostic technologies in pediatric populations. Draft definitions and statements were proposed and circulated widely for feedback. An expert panel then considered each of the proposed definitions and statements relating to clinical definitions. Formal group consensus rules were established and consensus was reached for each statement. The definitions presented in this article are intended for use in clinical research to evaluate diagnostic assays and not for individual patient diagnosis or treatment decisions. A complementary article addresses methodological issues to consider for research of diagnostics in children with suspected tuberculosis.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Tuberculosis, Diagnostics, Children, Clinical Case Definitions, Intrathoracic Tuberculosis
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	02 Sep 2022 07:11
Last Modified:	02 Sep 2022 07:11
URI:	http://eprints.nirt.res.in/id/eprint/1154

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