Studies of immediate adverse reactions to different doses of a slow-release preparation of isoniazid

Parthasarathy, R and Devadatta, S and Fox, Wallace and Krishnaswami, K V and Radhakrishna, S and Somasundaram, P R and Tripathy, S P (1976) Studies of immediate adverse reactions to different doses of a slow-release preparation of isoniazid. Tubercle, 57 (2). pp. 115-121. ISSN 0041-3879

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Abstract

‘Double-blind’ studies were carried out to assess the incidence of immediate adverse reactions to different doses of a slow-release preparation of isoniazid (matrix isoniazid). Individual doses of 30 mg/kg matrix isoniazid were well-tolerated but higher doses resulted in giddiness, the incidence being dose-related. The giddiness was characterized by a late onset and was usually present even at 24 hours. A few patients complained of gastro-intestinal symptoms. It is concluded that matrix isoniazid can be given to Madras patients in doses of 30-40 mg/kg without risk of an undue incidence of immediate adverse reactions.

Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/123

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