Differential Codon Usage Pattern of HIV-1 tat Gene in Those with Slower and Faster Rates of Disease Progression.

Vidyavijayan, K K and Anangi, Brahmaiah and Banu, Brindha and Thiruvengadam, Kannan and Hassan, Sameer and Hanna, Luke Elizabeth (2017) Differential Codon Usage Pattern of HIV-1 tat Gene in Those with Slower and Faster Rates of Disease Progression. AIDS research and human retroviruses, 33 (9). pp. 900-901. ISSN 1931-8405

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Abstract

Codon usage has been identified as one of the most important factors that influence gene expression. The frequencies with which the different codons are used vary significantly between different organisms and also between the genes within the same organism. HIV has a remarkable nucleotide composition with an above average percentage of "A" nucleotides resulting in a codon usage pattern different from that of the human host. In this study, we compared the codon usage pattern of HIV-1 genes among different groups of HIV disease progressors to understand the influence of differential codon usage pattern on the pathogenic manifestation in the host.

Affiliation:	ICMR-National Institute for Research in Tuberuclosis
Item Type:	Article
Uncontrolled Keywords:	codon usage, HIV replication, disease pathogenicity, HIV-1 tat
Subjects:	Tuberculosis > HIV - Basic Science
Divisions:	Basic Science Research > Virology and Biotechnology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	25 Oct 2022 10:20
Last Modified:	25 Oct 2022 10:20
URI:	http://eprints.nirt.res.in/id/eprint/1574

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