An dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4 T cells.

Ashokkumar, Manickam and Sonawane, Aanand and Sathiyamani, Balakumaran and Esakialraj L, Bennett Henzeler and Hanna, Luke Elizabeth (2020) An dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4 T cells. Data in brief, 29. p. 105365. ISSN 2352-3409

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Abstract

This data article describes the infectivity of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses derived from primary CD4 T cells treated with or without IFN-α, over a period of 12 days. TF and NT viruses described in this article were derived from the same individual (one of each from 8 infants who acquired HIV infection through mother-to-child transmission (MTCT). IFN-α resistance to both TF and NT viruses was studied by infecting TZM-bl cells and measuring luciferase expression (expressed as relative light units, RLU). Measurement of luciferase expression is extremely sensitive and allows quantification of even small changes in gene expression at the transcriptional level.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Human immunodeficiency virus Mother-to-Child transmission Transmitted founder viruses Interferon alpha resistance
Subjects:	HIV Tuberculosis > Laboratory Research > Virological
Divisions:	Basic Science Research > Virology and Biotechnology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	15 Nov 2022 11:25
Last Modified:	15 Nov 2022 11:25
URI:	http://eprints.nirt.res.in/id/eprint/1744

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