Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis

Sampath, Pavithra and Rajamanickam, Anuradha and Kannan, T and Natarajan, Alangudi Palaniappan and Syeed Hissar, S. and Dhanapal, Madhavan and Thangavelu, Bharathiraja and Jayabal, Lavanya and Murugesan, Ramesh P. and Ranganathan, Uma Devi and Babu, Subash and Bethunaickan, Ramalingam (2023) Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis. Scientific Reports, 13 (1). p. 7404. ISSN Electronic: 2045-2322

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Abstract

Tuberculosis (TB) diagnosis still remains to be a challenge with the currently used immune based diagnostic methods particularly Interferon Gamma Release Assay due to the sensitivity issues and their inability in differentiating stages of TB infection. Immune markers are valuable sources for understanding disease biology and are easily accessible. Chemokines, the stimulant, and the shaper of host immune responses are the vital hub for disease mediated dysregulation and their varied levels in TB disease are considered as an important marker to define the disease status. Hence, we wanted to examine the levels of chemokines among the individuals with drug-resistant, drug-sensitive, and latent TB compared to healthy individuals. Our results demonstrated that the differential levels of chemokines between the study groups and revealed that CXCL10 and CXCL9 as potential markers of drug-resistant and drug-sensitive TB with better stage discriminating abilities.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Plasma, chemokines, CXCL10, CXCL9, potential diagnostic markers, drug-sensitive, drug-resistant, tuberculosis
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Mrs. N Lakshmi
Date Deposited:	12 May 2023 09:38
Last Modified:	12 Jan 2024 11:51
URI:	http://eprints.nirt.res.in/id/eprint/1957

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