Sex‑specific differences in systemic immune responses in MIS‑C children

Rajamanickam, A and Kumar, Nathella Pavan and Venkataraman, Aishwarya and Varadarjan, Poovazhagi and Selladurai, Elilarasi and Sankaralingam, Thangavelu and Thiruvengadam, Kannan and Selvam, Ramya and Thimmaiah, Akshith and Natarajan, Suresh and Ramaswamy, Ganesh and Putlibai, Sulochana and Sadasivam, Kalaimaran and Sundaram, Balasubramanian and Hissar, Syed and Ranganathan, Uma Devi and Babu, Subash (2024) Sex‑specific differences in systemic immune responses in MIS‑C children. Sex‑specific differences in systemic immune responses in MIS‑C children, 14(1) (1720).

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Abstract

Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare manifestation of Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2) infection that can result in increased morbidity and mortality. Mounting evidence describes sex disparities in the clinical outcomes of coronavirus disease 2019 (COVID-19). However, there is a lack of information on sex-specific differences in immune responses in MIS-C. This study is an observational and cross-sectional study and we wanted to examine immune parameters such as cytokines, chemokines, acute phase proteins (APPs), growth factors, microbial translocation markers (MTMs), complement components and matrix metalloproteinases (MMPs) in MIS-C children, based on sex. Male children were associated with heightened levels of pro-inflammatory cytokines—IFNγ, IL-2, TNFα, IL-1α, IL-1β, IL-6, IL-12, G-CSF and GM-CSF, chemokines-CCL2, CCL11, CXCL1, CXCL8 and CXCL10, acute phase proteins-α-2M, CRP,growth factors VEGF and TGFα, microbial translocation markers- iFABP, LBP, EndoCAb, complement components—C1q, MBL and C3 and matrix metalloproteinases MMP-8 and MMP-9 compared to female children with MIS-C. These results indicate that the heightened immune response in males is a characteristic feature of MIS-C. These findings might explain the differential disease pathogenesis in males compared to females with MIS-C and facilitate a deeper understanding of this disease.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Multisystem Infammatory Syndrome in Children (MIS-C);Severe Acute Respiratory Syndrome;immune responses in MIS-C;pro-inflammatory cytokines
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Mrs. N Lakshmi
Date Deposited:	26 Jul 2024 16:44
Last Modified:	01 Aug 2024 17:34
URI:	http://eprints.nirt.res.in/id/eprint/2009

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