Effect of oral exposure of mycobacterium avium intracellulare on the protective imunity induced by BCG

Sujatha, Narayanan and Paramasivan, C N and Prabhakar, R and Narayanan, P R (1986) Effect of oral exposure of mycobacterium avium intracellulare on the protective imunity induced by BCG. Journal of Biosciences, 10 (4). pp. 453-460. ISSN Print:0250-5991; Online: 0973-7138

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Abstract

The relative protective efficacy of oral administration of mycobacteria as compared to the conventional intradermal route of vaccination has been assessed in guinea pigs. Skin test reactivity to partially purified protein derivative and protective immunity to challenge with virulent Mycobacterium tuberculosis were used as parameters of protective immunity. Oral immunisation of guinea pigs either with BCG or with Mycobacterium avium intracellulare induces skin test reactivity and protective immunity comparable to that induced by intradermal route of vaccination. Oral exposure of Mycobacterium avium intracellulare prior to oral or intradermal dose of BCG did not interfere with the protective immunity induced by BCG in guinea pigs challenged with Mycobacterium tuberculosis H37Rv.

Item Type:	Article
Uncontrolled Keywords:	Protective immunity; BCG; oral immunisation, Mycobacterium tuberculosis H37Rv; Mycobacterium avium intracellulare
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	16 Aug 2013 05:59
Last Modified:	04 Oct 2016 09:44
URI:	http://eprints.nirt.res.in/id/eprint/207

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