Association of Mycobacterium Avium paratuberculosis with Crohn's Disease: A large multicentre study from TB endemic region

Vuyyuru, SK and Singh, U and Das, P and Basant, S and Singh, V and Sinha, SK and Sharma, K and Ramakrishnan, BS and Kannan, P and Pokharna, R and Malhotra, B and Bhatia, S and Dhali, GK and Sarkar, R and Sharma, C and Dattagupta, S and Singh, M and Kochhar, R and Kochhar, S and Ahuja, V (2026) Association of Mycobacterium Avium paratuberculosis with Crohn's Disease: A large multicentre study from TB endemic region. Association of Mycobacterium Avium paratuberculosis with Crohn's Disease: A large multicentre study from TB endemic region, 20(1) (jjaf23).

Text 202610.pdf - Published Version Download (467kB)

Abstract

The causal relationship between Crohn’s disease (CD) and Mycobacterium avium subspecies paratuberculosis (MAP) remains controversial. This multicenter observational study, conducted across 7 tertiary care centers in India, enrolled newly diagnosed, treatment-naive patients with CD as cases and treatment-naive patients with intestinal tuberculosis (ITB) or ulcerative colitis (UC) and healthy individuals undergoing sigmoidoscopy for hemorrhoids as controls. MAP detection was performed using serology for MAP antibodies, polymerase chain reaction (PCR), real-time quantitative PCR, and solid/liquid cultures of blood and colonic biopsy specimens. In situ PCR and immunohistochemistry were also applied to paraffin-embedded tissue sections to evaluate the presence of MAP across groups.

Affiliation:	ICMR- National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/2105

Actions (login required)

View Item