Diagnostic accuracy of low-complexity, manual nucleic acid amplification tests for the detection of pulmonary and extrapulmonary tuberculosis in adults and adolescents: a systematic review and meta-analysis*

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Inbaraj, LR and Srinivasalu, VA and Sathya Narayanan, MK and Bhaskar, A and Daniel, J and Scandrett, K and Korobitsyn, A and Ismail, N and Takwoingi, Y (2025) Diagnostic accuracy of low-complexity, manual nucleic acid amplification tests for the detection of pulmonary and extrapulmonary tuberculosis in adults and adolescents: a systematic review and meta-analysis*. Diagnostic accuracy of low-complexity, manual nucleic acid amplification tests for the detection of pulmonary and extrapulmonary tuberculosis in adults and adolescents: a systematic review and meta-analysis*, 6(10) (101169).

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Official URL: https://doi.org/10.1016/j.lanmic.2025.101169

Abstract

Low-complexity, manual nucleic acid amplification tests, such as loop-mediated isothermal amplification for tuberculosis (TB-LAMP), are among the molecular WHO-recommended rapid diagnostics and can provide results within a few hours, even in resource-limited settings. We aimed to synthesise evidence on the accuracy of these tests for the detection of pulmonary and extrapulmonary tuberculosis, to inform the 2024 update of the WHO consolidated guidelines on tuberculosis

Affiliation:	ICMR- National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/2129

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