In silico exploration of bioactive compounds from Acorus calamus L. for targeted treatment of ischemic heart disease: Molecular insights and therapeutic prospects

Umashankar, V (2024) In silico exploration of bioactive compounds from Acorus calamus L. for targeted treatment of ischemic heart disease: Molecular insights and therapeutic prospects. In silico exploration of bioactive compounds from Acorus calamus L. for targeted treatment of ischemic heart disease: Molecular insights and therapeutic prospects, 9(3) (150-57).

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Abstract

Ischemic heart disease (IHD) accounts for 80%–85% of mortality, highlighting the need to develop effective and noninvasive management strategies. Lekhana karma (therapeutic scrapping) helps in balancing the imbalanced Kapha and Medodhatu, which are important factors in the pathogenesis of IHD. Vacha—Acorus calamus Linn (AC) is 1 of the 10 Lekhaneeya drugs described in Charaka Samhita and is widely available and cost-effective. However, its bioactive phytoconstituents’ mode of action and molecular entities remain unexplored. Hence, this study aimed to elucidate the mode of action of its bioactive compounds and their interaction with IHD disease targets and pathways.

Affiliation:	ICMR-National Institute for Research in Tubercuosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/2165

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