Clinical effectiveness of three months once-weekly Isoniazid and Rifapentine regimen for treatment of Latent TB Infection: a systematic review and meta-analysis

Muniyandi, M and Kothoju, BC and Chelvanayagam, K and Balachandran, B and Palani, B and Janagaraj, V and Thirupathi, V and Nagarajan, K. (2026) Clinical effectiveness of three months once-weekly Isoniazid and Rifapentine regimen for treatment of Latent TB Infection: a systematic review and meta-analysis. Clinical effectiveness of three months once-weekly Isoniazid and Rifapentine regimen for treatment of Latent TB Infection: a systematic review and meta-analysis, 26(1) (1452).

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Abstract

Globally, multiple TB preventive treatment (TPT) regimens are available for Latent Tuberculosis Infection (LTBI) and implementing TPT is essential for achieving TB elimination. Standard treatments for LTBI include 9 and 6-month isoniazid monotherapy (9H and 6H) regimens, recent clinical trials also introduced the shorter once-weekly 3-month isoniazid plus rifapentine (3HP) regimen. To evaluate the clinical effectiveness of 3HP in adults, we performed a comprehensive synthesis on the clinical effectiveness (treatment completion, adverse drug reactions (ADRs) and exploratory analysis of incident active TB) of the 3HP regimen compared with 9H and 6H.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/2279

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