Monoclonal antibodies against mycobacterium avium/intracellulare

Paramasivan, C N and Jackett, Paul S and Coates, Anthony R M and Lowrie, Douglas B and Mirchison, D A (1988) Monoclonal antibodies against mycobacterium avium/intracellulare. Indian Journal of Medical Research, 88 (7). pp. 13-17. ISSN 0971-5916

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Abstract

Ten hybridoma cell lines prodacing monoclonaI antibodies (Mabs) against M. avium/intracellulare (Mai) serotype 8 were raised by the fusion of BALB/c mouse myeloma cells (SPZ) to spleen cells from immunized BALB/c mice. The specificity of the monoclonal antibodies was defined using their differing abilities to bind to sonicates from a range of mycobacterial species and strains. Tbe Mabs showed strain and species specificity. Three Mabs bound only to Mai serotype 8 and 1 Mab bound only to Mai serotypes 8 and 16, the only serotypes tested. The results indicate that Mabs specific for Mai species and serotypes can be produced. These could be useful for serodiagnostic and for epidemiological purposes.

Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/237

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