Intraspecies differentiation of strains of Mycobacterium tuberculosis obtained from Czechoslovakian, Mongolian and South Indian patients

Venkataraman, P and Paramasivan, C N and Ilampurnam, K J and Prabhakar, R (1988) Intraspecies differentiation of strains of Mycobacterium tuberculosis obtained from Czechoslovakian, Mongolian and South Indian patients. Indian Journal of Medical Research, 88 (Sept). pp. 211-216. ISSN 0971-5916

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Abstract

Twenty nine strains of M. tuberculosis from Czechoslovakia, 46 from Mongolia and 50 from South India were tested for virulence in the guineapig, sensitivity to thiophen-2-carboxylic acid hydrazide (TCH) and phage type. Most of the Czechoslovakian and Mongolian strains (93 and 80% respectively) were highly virulent in the guineapig while only 36 per cent of the South Indian strains showed high virulence. Similarly very high proportions of Czechoslovakian (97%) and Mongolian strains (85%) were resistant to TCH as against only 22 per cent of South Indian strains. The phage type I was observed in none of the Czechoslovakian strains, 4 per cent of Mongolian strains and in 68 per cent of South Indian strains. Thus, the Czechoslovakian and Mongolian strains, in general, resembled the classical M. tuberculosis, while the South Indian strains were generally of low virulence, susceptible to TCH and of phage type I. Evidence accumulated over the last two decades has shown that there exist within the species Mycobacterium tuberculosis, some variants and types on a subspecies level. The most prominent of these, the South Indian variant of M. tuberculosis, is distinguished by a number of characteristic features viz., lower virulence in the guineapig, enhanced susceptibility to hydrogen peroxide and thiopen-2-carboxylic acid hydrazide (TCH), natural resistance to thioacetazone and p-amino salicylic acid, clustering into an intermediate phage type I and characteristic composition of cell wall lipids1-5. However

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	26 Aug 2013 06:03
Last Modified:	15 Mar 2016 06:00
URI:	http://eprints.nirt.res.in/id/eprint/247

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