Induction of rifampicin metabolism during treatment of tuberculous patients with daily and fully intermittent regimens containing the drug

Immanuel, Chandra and Jayasankar, K and Narayana, A S L and Santha, T and Sundaram, V and Raghupati Sarma, G (1988) Induction of rifampicin metabolism during treatment of tuberculous patients with daily and fully intermittent regimens containing the drug. Indian Journal of Chest Diseases and Allied Sciences, 31 (4). pp. 251-257. ISSN 0377 9343

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Abstract

Self-induction of rifampicin metabolism during daily and intermittent chemotherapy was studied by monitoring the changes in the serum half-life of the drug over a 4-week period in patients with pulmonary tuberculosis. Rifampicin 450 mg was administered to 8 patients who received treatment daily, 7 on thrice-weekly and 7 others on twice-weekly treatment. Serum half-life was computed from concentrations of the drug determined at 3, 4½ and 6 hours after drug administration, on admission and at 1, 2 and 4 weeks after start of treatment. In the daily series, the mean serum half-life decreased from 4.9 hours on admission to 3.6 hours at 1 week (P = 0.02), and treatment beyond this had no further effect. In the thrice-weekly series, maximal induction was observed at the 2nd week, the mean values on admission and at 2 weeks being 5.8 and 3.7 hours, respectively (P < 0.01). In the twiceweekly series, maximal induction was observed only at the 4th week, the mean values on admission and at 4 weeks being 4.9 and 3.7 hours, respectively (P < 0.01). Serum activity of gamma glutamyl transferase was not found to be a suitable in vivo marker to monitor induction of the hepatic microsomal enzymes as no significant changes were observed in the activity of this enzyme in any of the 3 series during the 4-week period.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Biochemical
Divisions:	Basic Science Research > Biochemistry
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	26 Aug 2013 06:54
Last Modified:	15 Mar 2016 05:53
URI:	http://eprints.nirt.res.in/id/eprint/251

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