Treatment of pulmonary tuberculosis patients treated with short course chemotherapy regimens in South India - 5-year follow-up

Santha, T and Nazareth, O and Krishnamurthy, M S and Balasubramanian, R and Vijayan, V K and Janardhanam, B and Venkataraman, P and Tripathy, S P and Prabhakar, R (1989) Treatment of pulmonary tuberculosis patients treated with short course chemotherapy regimens in South India - 5-year follow-up. Tubercle, 70 (4). pp. 229-234. ISSN 0041-3879

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Abstract

A controlled clinical trial of three short-course chemotherapy regimens was undertaken in patients with newly diagnosed bacteriologically positive pulmonary tuberculosis. The patients were randomly allocated to receive one of three regimens: rifampicin, streptomycin, isoniazid and pyrazinamide daily for 2 months, followed by streptomycin, isoniazid and pyrazinamide twice weekly for 3 months (R/5) or for 5 months (R/7), or the same regimen as R/7 but without rifampicin (Z/7). A bacteriological relapse requiring retreatment occurred by 5 years in 7.1 % of 126 R/5, 4.0 % of 124 R/7 and 6.7 % of 253 Z/7 patients with organisms initially sensitive to streptomycin and isoniazid; none of these differences is statistically significant. Of the 31 relapses, 16 occurred within 2 years of the completion of chemotherapy and the remaining 15 between 2 and 5 years. Among 65 patients with initial drug resistance to streptomycin or isoniazid or both, there were six bacteriological relapses requiring retreatment.

Item Type:	Article
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	29 Aug 2013 09:08
Last Modified:	14 Mar 2016 10:15
URI:	http://eprints.nirt.res.in/id/eprint/262

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