Gastro-intestinal absorption of isoniazid and rifampicin in patients with intestinal tuberculosis

Gurumurthy, Prema and Ramachandran, Rajeswari and Balasubramanian, Rani and Rahman, Fathima and Victor, Lalitha and Narayana, A S L and Raghupati Sarma, G (1990) Gastro-intestinal absorption of isoniazid and rifampicin in patients with intestinal tuberculosis. Indian Journal of Tuberculosis, 37 (5). pp. 5-10. ISSN 0019-5705

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Abstract

The gastro-intestinal absorption of isoniazid and rifampicin was studied in 12 patients with intestinal tuberculosis (10 slow and 2 rapid acetylators of isoniazid) and compared with that in 18 patients with pulmonary tuberculosis (8 slow and 10 rapid acetylators). Exposure (area under the time-concentration curve), calculated on the basis of serum concentrations of the two drugs at 1, 2, 3, 6 and 8 hours, and the proportion of dose of isoniazid excreted in urine collected over the period (0-8½) hours as isoniccotinyl compounds after drug administration were similar in the 2 groups suggesting no impairment of gastro-intestinal absorption of the 2 drugs in patients with intestinal tuberculosis. It was also observed that there was no delay in the absorption of the 2 drugs in patients with intestinal tuberculosis as compared to that in patients with pulmonary tuberculosis. The absorption of D-xylose, used to assess the absorptive capacity of the proximal small intestine, was also similar and normal in both groups of patients.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Biochemical
Divisions:	Basic Science Research > Biochemistry
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	30 Aug 2013 09:46
Last Modified:	14 Mar 2016 09:27
URI:	http://eprints.nirt.res.in/id/eprint/277

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