Expression of the herpes simplex virus type 1 glycoprotein C gene requires sequences in the 5' noncoding region of the gene

Weir, J P and Narayanan, P R (1990) Expression of the herpes simplex virus type 1 glycoprotein C gene requires sequences in the 5' noncoding region of the gene. Journal of Virology, 64 (1). pp. 445-449. ISSN Print: 0022-538X; Online: 1098-5514

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Abstract

The role of the 5' noncoding region of the herpes simplex virus type 1 glycoprotein C (gC) gene in viral gene expression was investigated with recombinant herpesviruses that contained the bacterial 13-galactosidase gene under the control of the gC promoter-regulatory region. Each of these viruses had the same DNA sequences from the start of gC transcription upstream to -114 but had variable segments of the downstream 140-base-pair sequence that is between the start of gC transcription and translation. Analysis of 13-galactosidase expression and mRNA synthesis from these viruses demonstrated the importance of DNA sequences from the start of gC transcription downstream to +38 for optimal expression from the gC promoter.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Bacteriological Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	30 Aug 2013 11:21
Last Modified:	14 Mar 2016 09:34
URI:	http://eprints.nirt.res.in/id/eprint/288

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