Fetal response to maternal ascariasis as evidenced by anti-ascariasis lumbricoides IgM antibodies in the cord blood.

Sanjeevi, C B and Vivekanandan, S and Narayanan, P R (1991) Fetal response to maternal ascariasis as evidenced by anti-ascariasis lumbricoides IgM antibodies in the cord blood. Acta Paediatrica Scandinavica, 80 (12). pp. 1134-1138. ISSN Online: 1651-2227

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Abstract

The immune response of the fetus to maternal infection with Ascaris lumbricoides was studied by estimating IgG and IgM antibodies, using ELISA, in 28 paired samples of mother and cord blood. A. lumbricoides adult male, cuticle and unembryonated egg antigen was used. Toxocara canis larva antigen was used as a specificity control. Presence of IgG in the cord blood does not signify fetal response, but the presence of IgM antibodies does. IgM antibodies to Ascaris adult male antigen were present in 27 out of 28 maternal sera and 1 out of 28 cord sera. All maternal sera and only 6 cord sera showed IgM antibodies against Ascaris cuticle and 20 out of 22 maternal sera and 8 out of 22 cord sera tested, showed IgM antibodies to Ascaris unembryonated egg antigen. Sixteen out of 22 maternal sera and none out of 22 cord sera showed IgM antibody against Toxocara canis antigen, ruling out cross reaction and transplacental leak. The results of our study suggest that the Ascaris infection can spread to the fetus and elicit immune response. Key words: Ascaris lumbricoides, cord blood, maternal blood, IgM antibodies.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	04 Sep 2013 09:45
Last Modified:	14 Mar 2016 08:43
URI:	http://eprints.nirt.res.in/id/eprint/303

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