Effect of administration of rifampicin on the adrenocortical function in patients with pulmonary tuberculosis

Raghupati Sarma, G and Immanuel, Chandra and Krishnamurthy, P V and Balasubramanian, Rani and Ramachandran, Geetha and Prabhakar, R (1992) Effect of administration of rifampicin on the adrenocortical function in patients with pulmonary tuberculosis. Indian Journal of Tuberculosis, 39 (1). pp. 21-28. ISSN 0019-5705

Preview

PDF 199212.pdf - Published Version Download (54kB)

Abstract

Adrenocortical function was studied on admission and during treatment in 57 newlydiagnosed patients with pulmonary tuberculosis, 16 of whom were treated with a daily regimen containing Rifampicin (R-7), 22 with a twiceweekly regimen containing the same drug (R-Z) and 19 with a daily regimen that did not contain Rifampicin (NR-7). In patients on daily treatment (R-7 and NR-7), there was a slight increase in plasma cortisol at 1 week followed by a decline; while the mean level at 4 weeks was similar to that on admission in the R-7 patients, that in the NR-7 patients was significantly lower (P < 0.01). No change was observed in the R-2 patients. A positive response to tetracosactrin was observed in the 7 R-7, 14 R-Z and 7 NR-7 patients on admission and in 6, 14 and 14, respectively at 4 weeks. The increase in the proportion of positive responders in the NH-7 patients was significant (P = 0.05). On admission, the diurnal rhythm of the release of cortisol, as assessed by changes in salivary cortisol, was disturbed in the patients with an evening rise in the cortisol levels; it had, however, reverted to a near-normal pattern after 2 months of treatment in all 3 groups of patients.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Biochemical
Divisions:	Basic Science Research > Biochemistry
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	11 Sep 2013 10:38
Last Modified:	14 Mar 2016 07:25
URI:	http://eprints.nirt.res.in/id/eprint/323

Actions (login required)

View Item