Kinetics of Serum and Cellular Interleukin-5 in Posttreatment Eosinophilia of Patients with Lymphatic Filariasis

Limaye, A P and Ottesen, E A and Kumaraswami, V and Abrams, J S and Regunathan, J and Vijayasekaran, V and Jayaraman, K and Nutman, T B (1993) Kinetics of Serum and Cellular Interleukin-5 in Posttreatment Eosinophilia of Patients with Lymphatic Filariasis. Journal of Infectious Diseases, 167 (6). pp. 1396-1400. ISSN Print 0022-1899; Online 1537-6613

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Abstract

eosinophilopoetic cytokines were assessed before and at frequent intervals after diethylcarbamazine treatment of Bancroftian filariasis. Eosinophil counts peaked at day 7 after the start of treatment (359% ± 118% of pretreatment levels) and declined to pretreatment levels by day 17. Serum interleukin (IL)-5, undetectable in 14 of 15 patients before treatment, rose sharply but transiently, with peak levels (32 = 7 pg/mL) 2 days after diethylcarbamazine treatment. Granulocytemacrophage colony-stimulating factor and IL-3 were not detectable in serum at any time. In vitro mitogen-induced IL-5 levels decreased significantly in 7 of 9 patients 3 days after treatment when serum IL-5 was at near-peak levels. By day 10 IL-5 values increased in 8 of 9 patients compared with treatment values (P < .02). These data define the temporal relation between serum IL-5 levels and the subsequent development of eosinophilia and suggest that lymphocytes are the source of IL-5.

Item Type:	Article
Subjects:	Tuberculosis > Clinical Research Filariasis
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	17 Sep 2013 10:32
Last Modified:	14 Mar 2016 06:22
URI:	http://eprints.nirt.res.in/id/eprint/334

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