'Flu' syndrome associated with other systemic manifestations with once a month rifampicin in the treatment of multi-bacillary leprosy

Thomas, A and Joseph, P and Prabhakar, R (1993) 'Flu' syndrome associated with other systemic manifestations with once a month rifampicin in the treatment of multi-bacillary leprosy. Indian Journal of Leprosy, 65 (2). pp. 219-224. ISSN 0024-1024

Preview

PDF 199324.pdf - Published Version Download (22kB)

Abstract

Rifampicin, a potent bactericidal drug, has become an essential component of multidrug treatment regimens for tuberculosis and leprosy. One of the adverse reactions described following twice weekly or once weekly administration of rifampicin is the “‘Flu” syndrome (Sister Mary Aquinas et al 1972, Girling & Wallace 1971). This syndrome is immunological in nature and is often associated with the presence of circulating rifampicin - dependent anti-bodies (Riska & Mattson 1972, Proceedings of Workshop 1973). Initially it was thought to be uncommon with longer intervals between doses of the drug, i.e., once a month administration, as advocated in the chemotherapy of leprosy (WHO 1982). However, there have been a few reports about the occurrence of “Flu” syndrome with a regimen containing rifampicin once a mouth (Naafs & Matemera 1986, Parking & Shah 1989, Patki et al 1988, Vaz et al 1989). We report here three cases of leprosy developing “Flu” syndrome, associated with other systemic manifestations, during the monthly phase of their treatment.

Item Type:	Article
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	23 Sep 2013 10:21
Last Modified:	14 Mar 2016 07:00
URI:	http://eprints.nirt.res.in/id/eprint/354

Actions (login required)

View Item