Protective response in guineapigs exposed to Mycobacterium avium intracellulare/ M. scrofulaceum, BCG & south Indian isolates of M. tuberculosis

Herbert, D and Paramasivan, C N and Prabhakar, R (1994) Protective response in guineapigs exposed to Mycobacterium avium intracellulare/ M. scrofulaceum, BCG & south Indian isolates of M. tuberculosis. Indian Journal of Medical Research, 99 (Jan). pp. 1-7. ISSN 0971-5916

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Abstract

The protective immunity resulting from exposure to nontuberculous mycobacteria (NTM), BCG and virulent mycobacteria in different sequences was studied in the guineapig model employing strains prevalent in the south Indian BCG trial area and time kinetics to observe the immuno-modulation. The findings suggest that during the early course of challenge infection in guineapigs there was no interference with the immunity due to BCG, by prior exposure to NTM. In the animals sensitised with M. avium intracellulare before immunisation, the challenge infection was localised and confined to the site of inoculation, and only a few organisms reached the spleen.. However, at the later stages of the infection, as seen by the spleen viable counts at 12 wk, it appeared that the barrier at the localised site of infection may not be intact in the animals with prior exposure to NTM, and a few organisms disseminate to the spleen.

Item Type: Article
Uncontrolled Keywords: BCG, immunomodulation, non-tuberculous mycobacteria, spleen viable counts, south Indian isolates
Subjects: Tuberculosis > Laboratory Research > Bacteriological
Divisions: Basic Science Research > Bacteriology
Depositing User: Rathinasabapati R
Date Deposited: 24 Sep 2013 06:18
Last Modified: 14 Mar 2016 05:56
URI: http://eprints.nirt.res.in/id/eprint/369

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