Newer antimycobacterial drugs and their role in the treatment of tuberculosis patients

Paramasivan, C N (1994) Newer antimycobacterial drugs and their role in the treatment of tuberculosis patients. Indian Journal of Tuberculosis, 41 (1). pp. 7-16. ISSN 0019-5705

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Abstract

The main lesion in pulmonary tuberculosis, the pulmonary cavity, contains a large number of mycobacteria (about 108 colony forming units). Of these, a large bacillary population is located in the thin liquid caseous layer that covers the inner part of the cavitary wall. Here, the bacilli are extracellular which multiply actively because of the availability of oxygen and nutritive substances. There are at least 2 other bacillary populations, one inside macrophages and another inside solid caseous foci; both these populations are limited in size because environmental conditions are unfavourable for their growth.1 Among the organisms in these 3 populations, which are normally drug sensitive, drug resistant mutants develop at a mean frequency of about 10-6.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	24 Sep 2013 08:24
Last Modified:	14 Mar 2016 05:58
URI:	http://eprints.nirt.res.in/id/eprint/379

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