Effect of Anti-tuberculosis Drugs on the Iron- Sequestration Mechanisms of Mycobacteria

Raghu, B and Raghupati Sarma, G and Venkatesan, P (1995) Effect of Anti-tuberculosis Drugs on the Iron- Sequestration Mechanisms of Mycobacteria. Indian Journal of Pathology and Microbiology, 38 (3). pp. 287-292. ISSN 0377-4929

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Abstract

The effect of sub-lethal concent-rations of isoniazid, ethambutol, rifampicin and pyrazinamide on the growth in vitro and the production of both exochelins and mycobactins by the high virulent and the South Indian low virulent strains of M. tuberculosis was examined under iron-deficient and iron-rich conditions. There was a marked decrease in the growth of both strains in the presence of increasing concentrations of all four drugs, the inhibition being total in the presence of minimal inhibitory concentrations of the drugs. It was also observed that the growthinhibitory effect of all four drugs was slightly reversed in the presence of high concentration of iron in the medium. A significant increase was observed in the concentrations of both siderophores in the presence of all four drugs, under both iron-deficient (or) iron-rich conditions.

Item Type: Article
Uncontrolled Keywords: Anti-tuberculosis drugs, Iron transport, Mycobacteria
Subjects: Tuberculosis > Laboratory Research > Biochemical,Clinical and Pharmacological
Divisions: Basic Science Research > Biochemistry and Pharmacology
Depositing User: Rathinasabapati R
Date Deposited: 26 Sep 2013 07:53
Last Modified: 14 Mar 2016 05:27
URI: http://eprints.nirt.res.in/id/eprint/397

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