A controlled clinical trial of short course chemotherapy for tuberculoma of the brain

Rajeswari, R and Sivasubramanian, S and Balambal, R and Parthasarathy, R and Ranjani, R and Santha, T and Somasundaram, P R and Ganapathy, S and Sudarsana, K and Sayeed, Z A and Kalyanaraman, S and Prabhakar, R (1995) A controlled clinical trial of short course chemotherapy for tuberculoma of the brain. Tubercle and Lung Disease, 76 (4). pp. 311-317. ISSN 0962-8479

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Abstract

Objective: The efficacy of a short-course regimen in the treatment of brain tuberculoma and computerised tomography (CT) scan appearance before, during and after antituberculosis treatment was studied in a controlled clinical trial. Design: Patients aged over 5 years with tuberculoma of the brain diagnosed by CT scan were randomly allocated to one of the following 2 regimens: Regimen 1: rifampicin, isoniazid and pyrazinamide daily for an initial 3 months followed by rifampicin and isoniazid twice-weekly for 6 months. Regimen 2: rifampicin, isoniazid and pyrazinamide thrice-weekly for an initial 3 months followed by rifampicin and isoniazid twice-weekly for 6 months. The patients were followed intensively for 2 years from the start of treatment. Results: Of the 108 patients analysed (regimen 1: 56, regimen 2: 52), at the end of treatment clinical status was normal in 91% in regimen 1 and 88% in regimen 2. Of the 91 patients with scan assessments, CT scan lesions disappeared at 24 months in 77% of 47 patients in regimen 1 and 80% of 44 in regimen 2, and in both groups 88% of the patients were clinically normal. None had relapses requiring treatment. Conclusions: Short-course regimens of 9 months’ duration are effective in the treatment of tuberculoma of the brain; clinical recovery was faster than scan clearance.

Item Type:	Article
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	26 Sep 2013 09:34
Last Modified:	14 Mar 2016 05:28
URI:	http://eprints.nirt.res.in/id/eprint/398

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