In vitro susceptibility of Mycobacterium tuberculosis to trifluoperazine

Selvakumar, N and Kumar, V and Krishnamurthy, P V and Prabhakar, R and Murthy, P S (1997) In vitro susceptibility of Mycobacterium tuberculosis to trifluoperazine. Current Science, 73 (1). pp. 79-80. ISSN 0011-3891

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Abstract

The reference strain, Mycobacterium tuberculosis H37Rv, 19 drug-sensitive and 15 drug resistant clinical isolates of M. tuberculosis were tested for their in vitro susceptibility to trifluoperazine (TFP), an antipsychotic drug, by broth dilution method. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of TFP against M. tuberculosis H37Rv were 8 and 32 mg/l, respectively. The distribution of the sensitive and resistant isolates, with respect to the MIC of TFP, was similar. The distribution of the sensitive and resistant isolates, with respect to the MBC of TFP, was different and the difference was statistically significant. The findings suggest that TFP is more bactericidal to drug-resistant isolates than to the sensitive isolates.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	29 Oct 2013 07:40
Last Modified:	14 Mar 2016 04:48
URI:	http://eprints.nirt.res.in/id/eprint/445

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