Short-course chemotherapy for tuberculosis of the spine : A comparison between ambulant treatment and radical surgery - a ten year report.

Parthasarathy, R and Sriram, K and Santha, T and Prabhakar, R and Somasundaram, P R and Sivasubramanian, S (1999) Short-course chemotherapy for tuberculosis of the spine : A comparison between ambulant treatment and radical surgery - a ten year report. The Journal of Bone and Joint Surgery (Britain), 81-B (3). pp. 464-471. ISSN Print:2049-4394; Online: 2049-4408

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Abstract

We perfomed a randomised, controlled clinical trial to compare ambulant short-course chemotherapy with anterior spinal fusion plus short-course chemotherapy for spinal tuberculosis without paraplegia. Patients with active disease of vertebral bodies were randomly allocated to one of three regimens: a) radical anterior resection with bone grafting plus six months of daily isoniazid plus rifampicin (Rad6); b) ambulant chemotherapy for six months with daily isoniazid plus rifampicin (Amb6); or c) similar to b) but with chemotherapy for nine months (Amb9). Ten years from the onset of treatment, 90% of 78 Rad6, 94% of 78 Amb6 and 99% of 79 Amb9 patients had a favourable status. Ambulant chemotherapy for a period of six months with daily isoniazid plus rifampicin (Amb6) was an effective treatment for spinal tuberculosis except in patients aged less than 15 years with an initial angle of kyphosis of more than 30° whose kyphosis increased substantially.

Item Type:	Article
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	04 Nov 2013 07:51
Last Modified:	10 Mar 2016 08:55
URI:	http://eprints.nirt.res.in/id/eprint/492

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