Cytochrome P-450 in drug-resistance Mycobacterium tuberculosis

Ramachandran, G and Gurumurthy, P and Narayanan, P R and Mahadevan, U (1999) Cytochrome P-450 in drug-resistance Mycobacterium tuberculosis. Current Science, 76 (9). pp. 1231-1234. ISSN 0011-3891

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Abstract

Methods for the isolation and spectrophotometric determination of cytochrome P-450 in mycobacteria were standardized. Cytochrome P-450 levels were estimated in Mycobacterium tuberculosis organisms sensitive to both isoniazid and rifampicin and resistant to any of the two drugs. Cytochrome P-450 was isolated and its presence was shown in M.smegmatis, M.fortuitum, M.chelonae and M. tuberculosis H37Rv. The cytochrome P-450 content was significantly elevated in M. tuberculosis , resistant to both isoniazid and rifampicin when compared with the corresponding sensitive strains. It therefore appears that cytochrome P-450 might play a role in causing drug resistance in tuberculosis.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Biochemical
Divisions:	Basic Science Research > Biochemistry
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	04 Nov 2013 08:01
Last Modified:	10 Mar 2016 08:56
URI:	http://eprints.nirt.res.in/id/eprint/493

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