Comparison of the sensitivity to Thiacetazone of Tubercle bacilli from patients in Britain, East Africa, South India and Hong Kong.

Mitchison, D A and Llyod, Janet (1964) Comparison of the sensitivity to Thiacetazone of Tubercle bacilli from patients in Britain, East Africa, South India and Hong Kong. Tubercle, 45 (4). pp. 360-369. ISSN 0041-3879

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Abstract

Sensitivity tests to thiacetazone were done on cultures of tubercle bacilli obtained from 23 British, 27 East African, 30 South Indian and 48 Hong Kong patients with less than 11 days of previous antituberculosis chemotherapy and with isoniazid-sensitive organisms and from 38 Hong Kong patients with more than 14 days previous chemotherapy and/or isoniazid-resistant organisms. The results were expressed in three ways, one of which was the minimal concentration of thiacetazone inhibiting growth, where growth is defined as a viable count of 0.1 per cent of the count on drug-free medium (the 0.1 % MIC). The 0.1% MIC was 1 μg/ml. thiacetazone or more with 13 % of the British cultures, 19 % of the African cultures, 73 % of the Indian cultures and 70 % of the Hong Kong cultures. The other assessments of sensitivity to thiacetazone also indicated that the Indian and the Hong Kong cultures were more resistant to thiacetazone than the British and the African cultures. No associations were found between the sensitivity to thiacetazone and the sensitivity to isoniazid or to streptomycin in the Hong Kong cultures. Thiacetazoneresistant cultures from Indian patients were more often of low virulence in the guinea-pig than sensitive cultures, but no such association was found in the 15 Hong Kong cultures tested.

Item Type:	Article
Subjects:	Tuberculosis > Operational Research
Divisions:	Epidemiology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	17 Jul 2013 04:29
Last Modified:	08 Mar 2016 04:44
URI:	http://eprints.nirt.res.in/id/eprint/59

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