Virulence in the guinea-pig and sensitiviy to PAS and thiacetazone of tubercle bacilli from South Indian patients with pulmonary tuberculosis.

Joseph, S and Mitchison, D A and Ramachandran, K and Selkon, J B and Subbaiah, T V (1964) Virulence in the guinea-pig and sensitiviy to PAS and thiacetazone of tubercle bacilli from South Indian patients with pulmonary tuberculosis. Tubercle, 45 (4). pp. 354-359. ISSN 0041-3879

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Abstract

Isoniazid-sensitive strains of tubercle bacilli, obtained pretreatment from 280 South Indian patients, were tested for their virulence in the guinea-pig and for their sensitivity to PAS; strains from 209 of these patients were also tested for their sensitivity to thiacetazone. Strains of low virulence more often had a high proportion of PAS-resistant mutants and were more often resistant to thiacetazone than those of high virulence. There is suggestive evidence that Indian strains can be divided into two groups, the smaller group, comprising about one-quarter of the strains, resembling strains from British patients and the larger group characterized by a lower virulence, a higher susceptibility to hydrogen peroxide, a higher proportion of PAS-resistant mutants and thiacetazone resistance.

Item Type:	Article
Subjects:	Tuberculosis > Operational Research
Divisions:	Epidemiology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	17 Jul 2013 04:34
Last Modified:	08 Mar 2016 04:44
URI:	http://eprints.nirt.res.in/id/eprint/60

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