Association of vitamin D receptor gene variants of BsmI, ApaI and FokI polymorphisms with susceptibility or resistance to pulmonary tuberculosis

Selvaraj, P and Chandra, G and Kurian, Sunil Mathan and Reetha, A M and Narayanan, P R (2003) Association of vitamin D receptor gene variants of BsmI, ApaI and FokI polymorphisms with susceptibility or resistance to pulmonary tuberculosis. Current Science, 84 (12). pp. 1564-1563. ISSN 0011-3891

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Abstract

Vitamin D receptor (VDR) gene polymorphism was studied to find out whether the variants of this gene are associated with susceptibility or resistance to pulmonary tuberculosis (PTB) and bacteriological relapse of tuberculosis. BsmI, ApaI and FokI polymorphisms of VDR gene were studied in PTB patients (n = 120), patient contacts (spouses of the patients; n = 80), bacteriological relapse patients (n = 48) and quiescent patients (n = 48). Significant increase of Bb genotype (heterozygote carrier) of BsmI polymorphism (P = 0.028) and FF genotype (homozygotes of common allele F) of FokI polymorphism (P = 0.034) were observed in male PTB patients than male contacts. The BB genotype (homozygote of common allele B) of BsmI polymorphism and AA genotype (homozygote of common allele A) of ApaI polymorphism were increased in male contacts than male PTB patients (BB: P = 0.018; AA: P = 0.04). No significant differences were found among female patients and female contacts. In bacteriological relapse cases of PTB, a decreased frequency of AA genotype (P = 0.015) and an increased frequency of Aa genotype (P = 0.024) were observed in bacteriological relapse patients than quiescent patients of PTB. The present study suggests that Bb genotype of BsmI polymorphism and FF genotype of FokI polymorphism of VDR gene may be associated with the susceptibility to tuberculosis in males. The BB and AA genotypes may be associated with resistance to PTB in males. The genotype Aa may be associated with bacteriological relapse and AA may be associated with protection against bacteriological relapse.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	13 Nov 2013 11:20
Last Modified:	09 Mar 2016 11:04
URI:	http://eprints.nirt.res.in/id/eprint/621

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