Thomas, A and Gopi, P G and Santha, T and Chandrasekaran, V and Subramani, R and Selvakumar, N and Eusuff, S I and Sadacharam, K and Narayanan, P R (2005) Predictors of relapse among pulmonary tuberculosis patients treated in a DOTS programme in South India. International Journal of Tuberculosis and Lung Disease, 9 (5). pp. 556-561. ISSN Print: 1027-3719; Online: 1815-7920
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Abstract
OBJECTIVE: To identify risk factors associated with relapse among cured tuberculosis (TB) patients in a DOTS programme in South India. DESIGN: Sputum samples collected from a cohort of TB patients registered between April 2000 and December 2001 were examined by fluorescence microscopy for acidfast bacilli and by culture for Mycobacterium tuberculosis at 6, 12 and 18 months after treatment completion. RESULTS: Of the 534 cured patients, 503 (94%) were followed up for 18 months after treatment completion. Of these, 62 (12%) relapsed during the 18-month period; 48 (77%) of the 62 relapses occurred during the first 6 months of follow-up. Patients who took treatment irregularly were twice more likely to have a relapse than adherent patients (20% vs. 9%; adjusted odds ratio [aOR] 2.5; 95%CI 1.4–4.6). Other independent predictors of relapse were initial drug resistance to isoniazid and/or rifampicin (aOR 4.8; 95%CI 2.0–11.6) and smoking (aOR 3.1; 95%CI 1.6–6.0). The relapse rate among nonsmoking, treatment adherent patients with drug-sensitive organisms was 4.8%. CONCLUSIONS: The relapse rate under the DOTS programme may be reduced by ensuring that patients take their treatment regularly and are counselled effectively about quitting smoking.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | tuberculosis; DOTS; India; relapse |
| Subjects: | Tuberculosis > Clinical Research |
| Divisions: | Clinical Research |
| Depositing User: | Dr. Rathinasabapati R |
| Date Deposited: | 22 Nov 2013 10:25 |
| Last Modified: | 09 Mar 2016 08:58 |
| URI: | http://eprints.nirt.res.in/id/eprint/680 |
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