A 5-Year Study of Patients with Pulmonary Tuberculosis in a Concurrent Comparison of Home and Sanatorium Treatment for One Year with Isoniazid plus PAS

Dawson, J J Y and Devadatta, S and Fox, Wallace and Radhakrishna, S and Ramakrishnan, C V and Somasundaram, P R and Stott, H and Tripathy, S P and Velu, S (1966) A 5-Year Study of Patients with Pulmonary Tuberculosis in a Concurrent Comparison of Home and Sanatorium Treatment for One Year with Isoniazid plus PAS. Bulletin of the World Health Organization, 34 (4). pp. 533-551. ISSN 00429686

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Abstract

This report from the Tuberculosis Chemotherapy Centre, Madras, summarizes the progress over a 5-year period of 193 patients with newly diagnosed, sputum-positive pulmonary tuberculosis who were admitted to a concurrent comparison of home and sanatorium treatment for one year with isoniazid plus PAS. Previous reports have shown that, despite the traditional advantages of sanatorium treatment-rest, adequate diet, nursing and supervised drug-administration-the home patients responded nearly as well as the sanatorium patients in the first year; further, the relapse rates over a 2-year period of follow-up were similar. The findings in the present report are based on a 4-year period of follow-up and extend these conclusions, the relapse rates over the period being 7 % for the home patients and 10 % for the sanatorium patients. Patients who failed to respond to treatment in the first year and those who had a bacteriological relapse in the second or subsequent years were usually re-treated with reserve regimens, first with streptomycin plus pyrazinamide and, if this was ineffective, with cycloserine plus ethionamide. Considering the findings over the entire 5-year period, five home patients and three sanatorium patients died from non-tuberculous causes. Of the remainder, 5 % of the home patients and 6 % of the sanatorium patients died of tuberculosis, 4 % in each series had bacteriologically active disease at five years and 90 % and 89 %, respectively, had bacteriologically quiescent disease at that time. These findings are very encouraging, particularly for developing countries such as India, where tuberculosis is a major problem and sanatorium beds are very few.

Item Type:	Article
Subjects:	Tuberculosis > Epidemiological Research Tuberculosis > Operational Research
Divisions:	Epidemiology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	17 Jul 2013 11:16
Last Modified:	08 Mar 2016 05:22
URI:	http://eprints.nirt.res.in/id/eprint/69

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