Pharmacokinetics of isoniazid and rifampicin in patients with renal failure undergoing continuous ambulatory peritoneal dialysis (CAPD) Running Head : Pharmacokinetic of INH & RMP in renal failure (CAPD)

Ramachandran, Geetha and Hemanth Kumar, A K and Gurumurthy, Prema and Prakash, K C and Venkatesan, P and Bose, S C and Datta, Manjula (2005) Pharmacokinetics of isoniazid and rifampicin in patients with renal failure undergoing continuous ambulatory peritoneal dialysis (CAPD) Running Head : Pharmacokinetic of INH & RMP in renal failure (CAPD). SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS, 2 (2). pp. 23-27. ISSN Print: 1818-9741; Online: 2091-0959

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Abstract

The pharmacokinetics of isoniazid (INH) and rifampicin (RMP) was determined in 22 renal failure patients, 11 each with low and high membrane permeabilities (LMP and HMP) undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD). Blood samples were collected at different time points following oral administration of INH and RMP. Estimations of INH and RMP in blood were carried out by standard procedures and certain pharmacokinetic variables were calculated based on their concentrations in blood. The INH inactivation status was determined based on salivary levels of INH. The pharmacokinetic variables of INH and RMP did not differ significantly between LMP and HMP groups. The study results suggest that renal failure patients on CAPD may not require reduction in the dosage of RMP or INH in rapid acetylators. Slow acetylators might require dose reduction of INH. Determination of INH inactivation status is important when patients with renal failure and tuberculosis are treated with INH-containing regimens.

Item Type: Article
Uncontrolled Keywords: Rifampicin, Isoniazid, Pharmacokinetics, Renal Failure, CAPD
Subjects: Tuberculosis > Laboratory Research > Biochemical
Divisions: Basic Science Research > Biochemistry
Depositing User: Dr. Rathinasabapati R
Date Deposited: 26 Nov 2013 11:03
Last Modified: 09 Mar 2016 08:41
URI: http://eprints.nirt.res.in/id/eprint/694

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