Short-course chemotherapy for paediatric respiratory tuberculosis: 5-year report

Swaminathan, S and Raghavan, A and Duraipandian, M and Kripasankar, A S and Ramachandran, P (2005) Short-course chemotherapy for paediatric respiratory tuberculosis: 5-year report. International Journal of Tuberculosis and Lung Disease, 9 (6). pp. 693-696. ISSN Print: 1027-3719; Online: 1815-7920

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Abstract

This report presents the 5-year follow-up of 137 children with respiratory tuberculosis enrolled in a randomised clinical trial of two different anti-tuberculosis regimens 9HR and 2HRZ3/4RH2. Both regimens had similar cure rates, with low relapse rates and mortality. Of 134 children followed up to 5 years, 86% had normal radiographs, with more sequelae in the 9HR group (15% vs. 1.5%, P , 0.01). One patient relapsed and there was one accidental death. Short-course chemotherapy in children is safe, effective and well tolerated, and leads to excellent long-term results, with a small proportion of children left with radiological sequelae.

Item Type:	Article
Uncontrolled Keywords:	tuberculosis; short-course chemotherapy; randomised clinical trial; paediatric
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	29 Nov 2013 05:44
Last Modified:	09 Mar 2016 08:56
URI:	http://eprints.nirt.res.in/id/eprint/730

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