Cutting Edge: Diminished T Cell TLR Expression and Function Modulates the Immune Response in Human Filarial Infection

Babu, Subash and Blauvelt, C P and Kumaraswami, V and Nutman, T B (2006) Cutting Edge: Diminished T Cell TLR Expression and Function Modulates the Immune Response in Human Filarial Infection. Journal of Immunology, 176 (7). pp. 3885-3889. ISSN Print: 0022-1767; Online: 1550-6606

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Abstract

Patent lymphatic filariasis is characterized by profound Ag-specific T cell hyporesponsiveness with impaired IFN-� and IL-2 production. Because T cells have been shown to express a number of TLR and to respond to TLR ligands, we hypothesized that diminished T cell TLR function could partially account for the T cell hyporesponsiveness in filariasis. T cells expressed TLR1, TLR2, TLR4, and TLR9, and the baseline expression of TLR1, TLR2, and TLR4, but not TLR9 was significantly lower in T cells of the filarial-infected individuals compared with the uninfected individuals (both endemic and nonendemic). TLR function was significantly diminished in the T cells of filarial-infected individuals based on decreased T cell activation/cytokine production in response to TLR ligands. Thus, diminished expression and function of T cell TLR is a novel mechanism underlying T cell immune tolerance in lymphatic filariasis.

Item Type: Article
Subjects: Filariasis
Divisions: Basic Science Research > Immunology
Depositing User: Rathinasabapati R
Date Deposited: 03 Dec 2013 06:40
Last Modified: 09 Mar 2016 05:23
URI: http://eprints.nirt.res.in/id/eprint/741

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