Coincident filarial, intestinal helminth, and mycobacterial infection: helminths fail to influence tuberculin reactivity, but BCG influences hookworm prevalence

Lipner, E M and Gopi, P G and Subramani, R and Kolappan, C and Sadacharam, K and Kumaran, P and Prevots, D R and Narayanan, P R and Nutman, T B and Kumaraswami, V (2006) Coincident filarial, intestinal helminth, and mycobacterial infection: helminths fail to influence tuberculin reactivity, but BCG influences hookworm prevalence. American Journal of Tropical Medicine and Hygiene, 74 (5). pp. 841-847. ISSN 0002-9637

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Abstract

The prevalence of helminth and tuberculosis infections is high in South India, whereas Bacille-Calmette- Guerin (BCG) vaccine efficacy is low. Our aim was to determine whether concurrent helminth infection alters the ability to mount a delayed-type hypersensitivity response to tuberculin. In a cross-sectional study in southern India, individuals 6–65 years of age were screened for intestinal helminths, circulating filarial antigenemia, tuberculin reactivity, active tuberculosis, and history of BCG vaccination; 54% were purified protein derivative (PPD) positive, 32% had intestinal helminth infection, 9% were circulating filarial antigen positive, and 0.5% had culture-confirmed active tuberculosis. Only age and BCG vaccination were significantly associated with PPD reactivity; however, BCG vaccination was associated with a lower prevalence of hookworm infection relative to those without prior BCG vaccination. Neither intestinal helminth infection nor filarial infection was associated with diminished frequencies of PPD positivity. Our findings suggest that preceding helminth infection does not influence significantly the delayed-type hypersensitivity response to tuberculin.

Item Type:	Article
Subjects:	Tuberculosis > Epidemiological Research Filariasis
Divisions:	Epidemiology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	11 Dec 2013 11:17
Last Modified:	09 Mar 2016 06:12
URI:	http://eprints.nirt.res.in/id/eprint/757

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