Susceptibility of Mycobacterium tuberculosis Strains to Gatifl oxacin and Moxifl oxacin by Different Methods

Somasundaram, Sulochana and Paramasivan, C N (2006) Susceptibility of Mycobacterium tuberculosis Strains to Gatifl oxacin and Moxifl oxacin by Different Methods. Chemotherapy, 52 (4). pp. 190-195. ISSN Print: 0009-3157, Online: 1421-9794

[img] PDF
200656.pdf - Published Version
Restricted to Registered users only

Download (107kB) | Request a copy
Official URL: http://www.karger.com/Article/FullText/93486

Abstract

Background: Considering the potentials of gatifl oxacin and moxifl oxacin in the treatment of tuberculosis, the present study was aimed to defi ne resistance to both these drugs. Methods: Fifty Mycobacterium tuberculosis isolates, consisting of 30 ofl oxacin-susceptible and 20 ofl oxacin-resistant strains, were tested for their susceptibility to gatifl oxacin and moxifl oxacin using different susceptibility testing methods, namely the absolute concentration method on Lowenstein-Jensen medium (LJ), the proportion susceptibility testing method (PST) on LJ and 7H11 agar media, and the BACTEC radiometric method. Result: The minimal inhibitory concentration (MIC) of gatifl oxacin and moxifl oxacin was 1 � g/ml by the absolute concentration method on LJ. In the PST method on LJ and 7H11, using a criterion of 6 1% growth as resistant, there was 100% agreement with the absolute concentration method at a concentration of 0.5 � g/ ml for gatifl oxacin, and 96% agreement with the BACTEC method at a concentration of 0.25 � g/ml. For moxifl oxacin, results by the PST method showed 96% agreement with the absolute concentration method on LJ at a concentration of 1 � g/ml and 92% agreement at a concentration of 0.5 � g/ml for both the absolute concentration method on 7H11 and the BACTEC method. Conclusions: The MICs of gatifl oxacin and moxifl oxacin were much lower than the MICs of other quinolones like ofl oxacin and ciprofl oxacin. Additionally, these two drugs have shown a low mean MIC and low concentration as a definition of resistance, which might help in treating the patients with low levels of quinolone resistance.

Item Type: Article
Uncontrolled Keywords: Mycobacterium tuberculosis, � Gatifloxacin, � Moxifl oxacin
Subjects: Tuberculosis > Laboratory Research > Bacteriological
Divisions: Basic Science Research > Bacteriology
Depositing User: Rathinasabapati R
Date Deposited: 19 Dec 2013 10:45
Last Modified: 09 Mar 2016 06:29
URI: http://eprints.nirt.res.in/id/eprint/783

Actions (login required)

View Item View Item