Mycobacteriumsmegmatis bio¢lm formationand slidingmotility are a¡ected by the serine/threonine protein kinase PknF

Radha, Gopalaswamy and Sujatha, Narayanan and Jacobs, W R and Av-Gay, Yossef (2008) Mycobacteriumsmegmatis bio¢lm formationand slidingmotility are a¡ected by the serine/threonine protein kinase PknF. FEMS Microbiology Letters, 278. pp. 121-127. ISSN Print: 0378-1097; Online: 1574-6968

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Abstract

Eighteen ‘eukaryotic-like’ serine/threonine kinases are present in the Mycobacterium smegmatis genome. One of them encoded by the ORF 3677 demonstrates high similarity to the Mycobacterium tuberculosis protein kinase PknF. A merodiploid strain was generated, which showed reduced growth associated with irregular cell structure. The merodiploid strain displayed altered colony morphology, defective slidingmotility and biofilm formation. These data indicate a role for PknF in biofilm formation, possibly associated with alterations in glycopeptidolipid composition.

Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/856

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