Effect of n-3 Fatty Acid Supplementation on bllod glucose, Lipid Profile and cytokines in humans: A pilot study

Raghu, B and Venkatesan, P (2008) Effect of n-3 Fatty Acid Supplementation on bllod glucose, Lipid Profile and cytokines in humans: A pilot study. Indian Journal of Clinical Biochemistry, 23 (1). pp. 85-88. ISSN : 0970-1915; ESSN: 0974-0422

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Abstract

This study was undertaken to evaluate the effects of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines in humans. Twenty adult healthy subjects were supplemented with 1g/day fish oil concentrate capsules for 2 weeks. Fasting blood samples were taken at baseline and again after 2 week intervention. Fish oil supplementation significantly lowered fasting serum concentrations of total cholesterol , triacylglycerol, very low density lipoprotein and low density lipoprotein (P < 0.01). Also high density lipoprotein increased significantly compared with baseline value (P < 0.01). Fish oil did not significantly altere the fasting blood glucose concentration but significantly reduced the serum cytokines (P < 0.001). This study demonstrated that eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) supplementation altered serum lipids, lipoprotein and cytokine concentrations in normal human subjects even at the small dose of 660 mg of EPA plus DHA per day. It appears that EPA plus DHA can be a safe and perhaps beneficial supplement to inflammatory diseases.

Item Type:	Article
Uncontrolled Keywords:	n-3 fatty acid, Blood Glucose, Lipid profile, Cytokines
Subjects:	Tuberculosis > Biostatistics
Divisions:	Statistics
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	19 May 2017 10:48
Last Modified:	25 Mar 2021 06:38
URI:	http://eprints.nirt.res.in/id/eprint/861

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