Study of ABCB1 polymorphism (C3435T) in HIV-1-infected individuals from South India

Siddharth, B and Geetha, R and Ramesh, K and Hemanth Kumar, A K and Anitha, S and Padmapriyadarshini, C and Narendran, G and Menon, P A and Rajasekaran, S and Soumya, S (2008) Study of ABCB1 polymorphism (C3435T) in HIV-1-infected individuals from South India. British Journal of Clinical Pharmacology, 65 (5). pp. 791-792. ISSN Print: 0306-5251; Online:1365-2125

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Abstract

Studies on P-glycoprotein expression and function have revealed that a single nucleotide polymorphism (SNP) in the human ABCB1 gene at 3435 (C > T) results in altered expression and function of P-glycoprotein [1, 2].There have been reports of lower nelfinavir and efavirenz (EFV) concentrations associated with TT genotypes (mutant) of ABCB1 C3435T polymorphism [3, 4].Frequency distribution of this polymorphism is known to vary across populations [3, 5, 6]. We report the genotype distribution of ABCB1 C3435T in 179 individuals (126 HIV-infected and 53 healthy) from South India. The polymorphism was correlated with plasma 12 h EFV and 2 h nevirapine (NVP) concentrations in 55 and 71 patients, respectively. Plasma EFV and NVP were estimated by HPLC [7, 8]. Genotyping was carried out by PCR-RFLP [9].

Item Type: Article
Additional Information: DOI:10.1111/j.1365-2125.2007.03093.x
Subjects: Tuberculosis > Laboratory Research
Tuberculosis > Laboratory Research > Biochemical,Clinical and Pharmacological
Tuberculosis
Divisions: Basic Science Research > Biochemistry and Pharmacology
Depositing User: Rathinasabapati R
Date Deposited: 02 Jun 2017 07:33
Last Modified: 02 Jun 2017 07:33
URI: http://eprints.nirt.res.in/id/eprint/880

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